Let's Talk Chemistry- a science podcast by ChemTalk
Episode 67: Dr. John LaMattina on Drug Discovery, Pharma Innovation, and Industry Myths
April 29, 202643 min · 7,035 words
Show notes
Have you ever wondered why new medicines can take decades to be developed and why the process is so costly? On this exciting episode of Let’s Talk Chemistry edited by Presley Vu, hosts Amber Bakkum, Poorvi Iyer, and Nina Deng go behind-the-scenes of the pharmaceutical industry with Dr. John LaMattina, former president of Pfizer Global Research and Development and current biotech advisor. Dr.
Highlighted moments
only about one in 10 drugs that start in the, uh, in clinical trials ended up becoming, uh, uh, getting, uh, regulatory approval. And even then, there's no guarantee it'll be a commercial success.
“for small molecules, anything that had been on the market for nine years, uh, would be subject to price controls. For large molecules, uh, they had more time. I think it was 13 years before price controls would be set.”
“venture capitalists suddenly said, well, we're not going to invest as much in small molecules now because the return on investment isn't going to be as great.”
“one of the key people on the program at a, at a meeting where they were going to kill the drug got on his knees and begged them to put the compound into phase one studies.”
Transcript
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